14 January 2022 / A new scientific publication in Nature shows that the occurrence of mutations in plant genomes is not purely random, and their frequencies in populations do not only depend on the mechanisms of selection. However, it is now becoming evident that there are natural mechanisms in the genome which prevent specific genomic regions from frequent mutations. The published research sheds new light on evolutionary biology and, at the same time, raises questions in regard to the consequences of genetic engineering in plants.